Galactose-Deficient IgA Immune Complexes
Learn more about the role of galactose-deficient IgA
immune complexes in IgA nephropathy
Elevated levels of galactose-deficient IgA trigger an autoimmune response leading to the formation of pathogenic IgA immune complexes. IgA-containing immune complexes travel via systemic circulation and deposit in the mesangium, causing kidney inflammation and injury. Accumulation of immune complexes can lead to progressive deterioration of renal function and end-stage renal disease in patients with IgA nephropathy.1,2 Watch IgANexus faculty Dr Laura Mariani and guest expert Dr Chee Kay Cheung discuss the important role of immune complexes in IgA nephropathy.
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References: 1. Suzuki H, Novak J. IgA glycosylation and immune complex formation in IgA nephropathy. Semin Immunopathol. 2021 Oct 1;43(5):669–78. 2. Yeo SC, Cheung CK, Barratt J. New insights into the pathogenesis of IgA nephropathy. Pediatr Nephrol. 2018 May 1;33(5):763–77.