Gut Immunology
Connecting IgA from the Gut to Immune Complex Deposition in the
Kidney
Gut-associated lymphoid tissue is a major site of mucosal-type, galactose-deficient IgA production, which is thought to play a key role in the pathogenesis of IgA nephropathy.1 Watch IgANexus faculty Dr Brad Rovin and guest expert Dr Gregg Silverman explain how the gut-kidney axis may play a significant role in IgA nephropathy.
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References: 1. Selvaskandan, H., Barratt, J., & Cheung, C. K. (2022). Immunological drivers of IgA nephropathy: Exploring the mucosa–kidney link. Int J Immunogenet, 49, 8–1. https://doi.org/10.1111/iji.12561