Gut-Kidney Pathophysiology and Evidence
for a Role of the Gut in IgA Nephropathy
Learn how developments in the understanding of the gut-kidney connection in IgA nephropathy have paved the way for new therapeutic strategies.
IgA nephropathy is characterized by the deposition of pathogenic IgA in the glomeruli, leading to inflammation and damage in the kidneys. In this discussion, Dr. Chee Kay Cheung explains how a number of studies identify the gut as the main source of pathogenic IgA and how targeting the gut in IgA nephropathy may modify the course of the disease.1
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References: 1. Cheung, C.K., Alexander, S., Reich, H.N. et al. The pathogenesis of IgA nephropathy and implications for treatment. Nat Rev Nephrol (2024). https://doi.org/10.1038/s41581-024-00885-3