Gut Microbiome
Exploring the gut microbiome and its influence on the pathophysiology of IgA nephropathy
The gut microbiome and its impact on the microenvironment of the Peyer’s patches may modulate mucosal-type, galactose-deficient IgA production.1,2 Watch IgANexus faculty Dr Brad Rovin and guest expert Dr Gregg Silverman explain the complexities of the gut microbiome in IgA nephropathy.
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References: 1. Barratt J, Rovin BH, Cattran D, Floege J, Lafayette R, Tesar V, Trimarchi H, Zhang H (2020) Why Target the Gut to Treat IgA Nephropathy? Kidney Int Rep 5(10):1620–1624. 2. Selvaskandan, H., Barratt, J., & Cheung, C. K. (2022). Immunological drivers of IgA nephropathy: Exploring the mucosa–kidney link. Int J Immunogenet, 49, 8–1. https://doi.org/10.1111/iji.12561