Peyer’s Patches
Get to know the important role of Peyer’s patches in the pathogenesis of IgA nephropathy
Peyer’s patches, which are heavily concentrated within the gut-associated lymphoid tissue (GALT) of the ileum, have been identified as a major source of mucosal-type, galactose-deficient IgA found in the kidneys of IgA nephropathy patients.1,2 Listen to IgANexus faculty Dr Richard Lafayette and guest expert Dr Paolo Cravedi discuss the significant role of the Peyer’s patches in IgA nephropathy.
00:30:09
References: 1. Barratt J, Rovin BH, Cattran D, Floege J, Lafayette R, Tesar V, Trimarchi H, Zhang H (2020) Why Target the Gut to Treat IgA Nephropathy? Kidney Int Rep 5(10):1620–1624. 2. Sanchez-Russo, L., Rajasekaran, A., Bin, S., Faith, J., & Cravedi, P. (2022). The Gut and Kidney Crosstalk in Immunoglobulin A Nephropathy. Kidney360, 3(9), 1630.