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4-hit Hypothesis

The pathophysiology of IgA nephropathy is characterized by four “hits”, including the presence of excess circulating galactose deficient IgA1 and IgA or IgG autoantibodies which form complexes that deposit in the glomerular mesangium, causing kidney damage.1 Learn more about these pathways and recent research on the pathophysiology of IgA nephropathy.

The 4 Hits of IgA Nephropathy

Learn more about the 4 hits of IgA Nephropathy
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IgA Structure and Function

Learn more about the structure and function of the
IgA molecule in the pathogenesis of IgA nephropathy
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Galactose-Deficient IgA Immune Complexes

Learn more about the role of galactose-deficient IgA
immune complexes in IgA nephropathy
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References

1. Rajasekaran A, Julian BA, Rizk DV. IgA Nephropathy: An Interesting Autoimmune Kidney Disease. The American Journal of the Medical Sciences. 2021 Feb 1;361(2):176–94.