4-hit Hypothesis
The pathophysiology of IgA nephropathy is characterized by four “hits”, including the presence of excess circulating galactose deficient IgA1 and IgA or IgG autoantibodies which form complexes that deposit in the glomerular mesangium, causing kidney damage.1 Learn more about these pathways and recent research on the pathophysiology of IgA nephropathy.
References
1. Rajasekaran A, Julian BA, Rizk DV. IgA Nephropathy: An Interesting Autoimmune Kidney Disease. The American Journal of the Medical Sciences. 2021 Feb 1;361(2):176–94.