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Gut-Kidney Connection

IgA nephropathy is a progressive autoimmune disease characterized by immune complex deposition in the kidney.1 The gut mucosa is a key source of secretory IgA that contributes to pathogenic immune complex formation.2 Learn more about the role of the gut in the pathogenesis of IgA nephropathy.

IgA Nephropathy Disease Mechanism

Learn more about IgA nephropathy, an autoimmune
disease that affects the kidneys
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Gut-Kidney Pathophysiology and Evidence
for a Role of the Gut in IgA Nephropathy

Learn how developments in the understanding of the gut-kidney connection in IgA nephropathy have paved the way for new therapeutic strategies.
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Gut Immunology

Discover the complex role of gut immunology in IgA
nephropathy
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Gut Immunology

Basics of the Gut Immune System
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Gut Immunology

Production of IgA in the Gut
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Gut Immunology

Connecting IgA from the Gut to Immune Complex Deposition in the
Kidney
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Gut Microbiome

Exploring the gut microbiome and its influence on the pathophysiology of IgA nephropathy
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Peyer’s Patches

Get to know the important role of Peyer’s patches in the pathogenesis of IgA nephropathy
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References

1. Rajasekaran A, Julian BA, Rizk DV. IgA Nephropathy: An Interesting Autoimmune Kidney Disease. The American Journal of the Medical Sciences. 2021 Feb 1;361(2):176–94. 2. Barratt J, Rovin BH, Cattran D, Floege J, Lafayette R, Tesar V, Trimarchi H, Zhang H (2020) Why Target the Gut to Treat IgA Nephropathy? Kidney Int Rep 5(10):1620–1624.